RESEARCH

Microbes Derived from Unexplored Environments

갯벌, 극지, 화산섬 등의 극한환경에서 유래한 미생물로부터 신규 골격을 지니는 유용한 천연생리활성물질을 발굴함
Natural Products Mediated Insect-Bacteria Symbiosis

​곤충과 공생하는 미생물로부터 유용한 생리활성을 지니는 신약후보물질을 발굴하고 공생 메커니즘을 규명함​
Natural Products Mediated Plant-Bacteria Symbiosis

식물과 공생하는 미생물로부터 유용한 생리활성을 지니는 신약후보물질을 발굴하고 공생 메커니즘을 규명함
Human Gut Microbiome and Disease

인간의 주요 질병과 장내 미생물 간의 상관관계를 연구하며 질병을 유도하는 주요 인자와 분자 기전을 규명함
DISCOVERY OF NOVEL BIOACTIVE NATURAL PRODUCTS BASED ON COMPREHENSIVE CHEMICAL DATA ANALYSIS

Microbes have been regarded as prolific sources of drug candidates. Our research group investigates chemical profiles of microbes derived from various sources including unexplored environments, insect symbiosis, and plant symbiosis to discover bioactive secondary metabolites using various chemical data analysis.
IDENTIFICATION OF GENOME-DRIVEN BIOSYNTHETIC PATHWAY FROM MICROBES

Following development of advanced full genome sequencing technology, microbial bios​ynthetic gene clusters have been studied well. Our research group identifies biosynthetic pathways of novel natural products and discover new secondary metabolites by activation of criptic gene clusters in microbes, providing structural and biological insights of microbial natural products. 
HUMAN GUT MICROBIOME, PROBIOTICS, AND DISEASE

Since national institute of health (NIH) started transnational project "Human Microbiome" in 2007, numerous research have been studied and reported significant association between human disease and gut microbiome. Our research group investigate molecular mechanisms of human gut microbiome against health and disease to accelerate development of postbiotics.